The frequency and outcome of lupus nephritis: results from an international inception cohort study.

ABSTRACT:

Objective

To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort.

Methods

Patients in the Systemic Lupus International Collaborating Clinics inception cohort (≤15 months of SLE diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality of life was measured by the Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental and physical component summary scores.

Results

There were 1827 patients, 89% females, mean (s.d.) age 35.1 (13.3) years. The mean (s.d.) SLE duration at enrolment was 0.5 (0.3) years and follow-up 4.6 (3.4) years. LN occurred in 700 (38.3%) patients: 566/700 (80.9%) at enrolment and 134/700 (19.1%) duri

SUBMITTER: Hanly JG 

PROVIDER: S-EPMC4939728 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature