High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice.

ABSTRACT: Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether a high-fat diet (HFD) impacts ovarian function, long-term fertility, and local and systemic markers of inflammation independent of obesity. Five-week-old mice were fed either low-fat diet (control group-LF-Ln) or HFD for 10 wk and were divided based on body weight into high-fat obese (HF-Ob: >25 g) and high-fat lean (HF-Ln: <22 g). Ovaries were collected to assess ovarian follicles and to determine the degree of local inflammation. Serum proinflammatory cytokines were also measured. A group of a

SUBMITTER: Skaznik-Wikiel ME 

PROVIDER: S-EPMC4939738 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature