Associations between metabolic dysregulation and circulating biomarkers of fibrosis: the Cardiovascular Health Study.

ABSTRACT:

Aim

Fibrosis is one postulated pathway by which diabetes produces cardiac and other systemic complications. Our aim was to determine which metabolic parameters are associated with circulating fibrosis-related biomarkers transforming growth factor-β (TGF-β) and procollagen type III N-terminal propeptide (PIIINP).

Methods

We used linear regression to determine the cross-sectional associations of diverse metabolic parameters, including fasting glucose, fasting insulin, body mass index, fatty acid binding protein 4, and non-esterified fatty acids, with circulating levels of TGF-β (n = 1559) and PIIINP (n = 3024) among community-living older adults in the Cardiovascular Health Study.

Results

Among the main metabolic parameters we examined, only fasting glucose was associat

SUBMITTER: Agarwal I 

PROVIDER: S-EPMC4939831 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature