The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy.

ABSTRACT: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used classes of medications in the world. Unfortunately, NSAIDs induce an enteropathy associated with high morbidity and mortality. Although the pathophysiology of this condition involves the interaction of the gut epithelium, microbiota, and NSAIDs, the precise mechanisms by which microbiota influence NSAID enteropathy are unclear. One possible mechanism is that the microbiota may attenuate the severity of disease by specific metabolite-mediated regulation of host inflammation and injury. The microbiota-derived tryptophan-metabolite indole is abundant in the healthy mammalian gut and positively influences intestinal health. We thus examined the effects of indole administration on NSAID enteropathy. Mice (n = 5 p

SUBMITTER: Whitfield-Cargile CM 

PROVIDER: S-EPMC4939928 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature