Estimating Dengue Transmission Intensity from Case-Notification Data from Multiple Countries.

ABSTRACT:

Background

Despite being the most widely distributed mosquito-borne viral infection, estimates of dengue transmission intensity and associated burden remain ambiguous. With advances in the development of novel control measures, obtaining robust estimates of average dengue transmission intensity is key for assessing the burden of disease and the likely impact of interventions.

Methodology/principle findings

We estimated the force of infection (λ) and corresponding basic reproduction numbers (R0) by fitting catalytic models to age-stratified incidence data identified from the literature. We compared estimates derived from incidence and seroprevalence data and assessed the level of under-reporting of dengue disease. In addition, we estimated the relative contribution of primary

SUBMITTER: Imai N 

PROVIDER: S-EPMC4939939 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature