Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.

ABSTRACT: Host genetic variations play an important role in several pathogenic diseases, and we have previously provided strong evidences that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive Group A Streptococcus (GAS) infections, including sepsis and necrotizing soft tissue infections (NSTIs). Our initial studies with conventional mouse strains revealed that host genetic variations and sex differences play an important role in orchestrating the severity, susceptibility and outcomes of NSTIs. To understand the complex genetic architecture of NSTIs, we utilized an unbiased, forward systems genetics approach in an advanced recombinant inbred (ARI) panel of mouse strains (BXD). Through this approach, we uncovered interactions between

SUBMITTER: Chella Krishnan K 

PROVIDER: S-EPMC4939974 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature