Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

ABSTRACT:

Objective

Insulin-like growth factor-binding protein-3 (IGFBP3) is the major protein that binds with insulin-like growth factor-1 (IGF-1) and is considered to be involved in the development and progression of various cancers. We aimed to examine the association between prostate cancer (PCa) and the IGFBP3 gene-202A/C polymorphism.

Methods

A comprehensive search within PubMed, EMBASE, and Cochrane Library was conducted to identify all case-control studies up to October 30, 2015, for a meta-analysis. Pooled odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated using the fixed or random effects model.

Results

Eighteen studies including 10,538 cases and 10,078 controls were identified. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associate

SUBMITTER: Qie Y 

PROVIDER: S-EPMC4940022 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature