Neurologic signs and symptoms frequently manifest in acute HIV infection.

ABSTRACT:

Objective

To determine the incidence, timing, and severity of neurologic findings in acute HIV infection (pre-antibody seroconversion), as well as persistence with combination antiretroviral therapy (cART).

Methods

Participants identified with acute HIV were enrolled, underwent structured neurologic evaluations, immediately initiated cART, and were followed with neurologic evaluations at 4 and 12 weeks. Concurrent brain MRIs and both viral and inflammatory markers in plasma and CSF were obtained.

Results

Median estimated HIV infection duration was 19 days (range 3-56) at study entry for the 139 participants evaluated. Seventy-three participants (53%) experienced one or more neurologic findings in the 12 weeks after diagnosis, with one developing a fulminant neurologic

SUBMITTER: Hellmuth J 

PROVIDER: S-EPMC4940060 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature