Autism and epilepsy: A population-based nationwide cohort study.

ABSTRACT:

Objective

To investigate the risk of autism spectrum disorder (ASD) in individuals with epilepsy and in their first-degree relatives to determine shared etiology.

Methods

Through the Swedish Patient Register, we identified 85,201 individuals with epilepsy, as well as all their siblings (n = 80,511) and offspring (n = 98,534). Each individual with epilepsy was compared with 5 controls, matched for age, sex, calendar period, and county, while siblings and offspring were compared with siblings and offspring of controls. We excluded siblings and offspring with epilepsy. Using Cox regression, we calculated hazard ratios (HRs) for future diagnosis of ASD. Logistic regression was applied to calculate odds ratios (ORs) for prior diagnosis of ASD.

Results

During follow-up, 1,3

SUBMITTER: Sundelin HE 

PROVIDER: S-EPMC4940061 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature