Monitoring of 30 marker candidates in early Parkinson disease as progression markers.

ABSTRACT:

Objective

This was a longitudinal single-center cohort study to comprehensively explore multimodal progression markers for Parkinson disease (PD) in patients with recently diagnosed PD (n = 123) and age-matched, neurologically healthy controls (HC; n = 106).

Methods

Thirty tests at baseline and after 24 months covered nonmotor symptoms (NMS), cognitive function, and REM sleep behavior disorder (RBD) by polysomnography (PSG), voxel-based morphometry (VBM) of the brain by MRI, and CSF markers. Linear mixed-effect models were used to estimate differences of rates of change and to provide standardized effect sizes (d) with 95% confidence intervals (CI).

Results

A composite panel of 10 informative markers was identified. Significant relative worsening (PD vs HC) was seen w

SUBMITTER: Mollenhauer B 

PROVIDER: S-EPMC4940068 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature