Structural growth trajectories and rates of change in the first 3 months of infant brain development.

ABSTRACT:

Importance

The very early postnatal period witnesses extraordinary rates of growth, but structural brain development in this period has largely not been explored longitudinally. Such assessment may be key in detecting and treating the earliest signs of neurodevelopmental disorders.

Objective

To assess structural growth trajectories and rates of change in the whole brain and regions of interest in infants during the first 3 months after birth.

Design, setting, and participants

Serial structural T1-weighted and/or T2-weighted magnetic resonance images were obtained for 211 time points from 87 healthy term-born or term-equivalent preterm-born infants, aged 2 to 90 days, between October 5, 2007, and June 12, 2013.

Main outcomes and measures

We segmented whole-brain

SUBMITTER: Holland D 

PROVIDER: S-EPMC4940157 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature