Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones.

ABSTRACT: The global system for manufacturing seasonal influenza vaccines has been developed to respond to the natural evolution of influenza viruses, but the problem of antigenic mismatch continues to be a challenge in certain years. In some years, mismatches arise naturally due to the antigenic drift of circulating viruses after vaccine strain selection has already been made. In other years, antigenic differences between the vaccine virus and circulating viruses are introduced as part of the current system, which relies on the use of egg-adapted isolates as a starting material for candidate vaccine viruses (CVVs). Improving the current process for making vaccine viruses can provide great value. We have previously established a synthetic approach for rapidly generating influenza viruses in a vaccin

SUBMITTER: Suphaphiphat P 

PROVIDER: S-EPMC4940205 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature