Motor Protein Accumulation on Antiparallel Microtubule Overlaps.

ABSTRACT: Biopolymers serve as one-dimensional tracks on which motor proteins move to perform their biological roles. Motor protein phenomena have inspired theoretical models of one-dimensional transport, crowding, and jamming. Experiments studying the motion of Xklp1 motors on reconstituted antiparallel microtubule overlaps demonstrated that motors recruited to the overlap walk toward the plus end of individual microtubules and frequently switch between filaments. We study a model of this system that couples the totally asymmetric simple exclusion process for motor motion with switches between antiparallel filaments and binding kinetics. We determine steady-state motor density profiles for fixed-length overlaps using exact and approximate solutions of the continuum differential equations and compar

SUBMITTER: Kuan HS 

PROVIDER: S-EPMC4940618 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature