Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression.

ABSTRACT:

Background and purpose

The orphan nuclear receptor Nur77 is implicated in the survival and apoptosis of cancer cells. The purpose of this study was to determine whether and how Nur77 serves to mediate the effect of the inflammatory cytokine TNF-α in cancer cells and to identify and characterize new agents targeting Nur77 for cancer therapy.

Experimental approach

The effects of TNF-α on the expression and function of Nur77 were studied using in vitro and in vivo models. Nur77 expression was evaluated in tumour tissues from breast cancer patients. The anticancer effects of honokiol and its mechanism of action were assessed by in vitro, cell-based and animal studies.

Key results

TNF-α rapidly and potently induced the expression of Nur77 in breast cancer cells through act

SUBMITTER: Xie L 

PROVIDER: S-EPMC4940620 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature