Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer.

ABSTRACT:

Background

The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.

Methods

ANXA2 and ANXA4 immunohistochemical staining were performed on a cervical cancer tissue microarray consisting of 46 normal cervical epithelium samples and 336 cervical cancer cases and compared the data with clinicopathological variables, including the survival of cervical cancer patients.

Results

ANXA2 expression was lower in cancer tissue (p = 0.002), whereas ANXA4 staining increased significantly in cancer tissues (p < 0.001). ANXA2 expression was more pr

SUBMITTER: Choi CH 

PROVIDER: S-EPMC4940752 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature