Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids.

ABSTRACT:

Background

This single center, double-blinded, cross-over, placebo controlled clinical trial investigated the effect of oral α-cyclodextrin (α-CD), a soluble dietary fiber, on blood lipid and lipoprotein levels in healthy human subjects. α-CD, a cyclical polymer containing 6 glucose subunits, is currently sold as an over the counter food supplement and is also a common additive in many foods. α-CD forms a hydrophobic central cavity that binds lipids and has been shown in animal studies and in previous clinical trials to alter plasma lipid levels.

Methods

We screened for healthy subjects, males and females, between ages 18 to 75. Out of total 103 subjects interviewed, 75 subjects completed the study. Qualified individuals in each gender group were randomized into two groups i

SUBMITTER: Amar MJ 

PROVIDER: S-EPMC4941029 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature