Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

ABSTRACT:

Objective

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD).

Design

We constructed a novel hepatocyte-specific PPARα knockout (Pparα(hep-/-)) mouse model. Using this novel model, we performed transcriptomic analysis following fenofibrate treatment. Next, we investigated which physiological challenges impact on PPARα. Moreover, we measured the contribution of hepatocytic PPARα activity to whole-body metabolism and fibroblast growth factor 21 production during fasting. Finally, we determined the influence of hepatocyte-specific PPARα deficiency in different m

SUBMITTER: Montagner A 

PROVIDER: S-EPMC4941147 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature