Metformin in severe exacerbations of chronic obstructive pulmonary disease: a randomised controlled trial.

ABSTRACT:

Background

Severe exacerbations of COPD are commonly associated with hyperglycaemia, which predicts adverse outcomes. Metformin is a well-established anti-hyperglycaemic agent in diabetes mellitus, possibly augmented with anti-inflammatory effects, but its effects in COPD are unknown. We investigated accelerated metformin therapy in severe COPD exacerbations, primarily to confirm or refute an anti-hyperglycaemic effect, and secondarily to explore its effects on inflammation and clinical outcome.

Methods

This was a multicentre, randomised, double-blind, placebo-controlled trial testing accelerated metformin therapy in non-diabetic patients, aged ≥35 years, hospitalised for COPD exacerbations. Participants were assigned in a 2:1 ratio to 1 month of metformin therapy, escalated

SUBMITTER: Hitchings AW 

PROVIDER: S-EPMC4941151 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature