MICL controls inflammation in rheumatoid arthritis.

ABSTRACT:

Background

Myeloid inhibitory C-type lectin-like receptor (MICL, Clec12A) is a C-type lectin receptor (CLR) expressed predominantly by myeloid cells. Previous studies have suggested that MICL is involved in controlling inflammation.

Objective

To determine the role of this CLR in inflammatory pathology using Clec12A(-/-) mice.

Methods

Clec12A(-/-) mice were generated commercially and primarily characterised using the collagen antibody-induced arthritis (CAIA) model. Mechanisms and progress of disease were characterised by clinical scoring, histology, flow cytometry, irradiation bone-marrow chimera generation, administration of blocking antibodies and in vivo imaging. Characterisation of MICL in patients with rheumatoid arthritis (RA) was determined by immunohistochemis

SUBMITTER: Redelinghuys P 

PROVIDER: S-EPMC4941174 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature