Phenotypic and genetic variation in leptin as determinants of weight regain.

ABSTRACT:

Aims

Over 75% of obese subjects fail to maintain their weight following weight loss interventions. We aimed to identify phenotypic and genetic markers associated with weight maintenance/regain following a dietary intervention.

Subjects and methods

In the 2-year Dietary Intervention Randomized Controlled Trial, we assessed potential predictors for weight changes during the 'weight loss phase' (0-6 months) and the 'weight maintenance/regain phase' (7-24 months). Genetic variation between study participants was studied using single-nucleotide polymorphisms in the leptin gene (LEP).

Results

Mean weight reduction was -5.5% after 6 months, with a mean weight regain of 1.2% of baseline weight during the subsequent 7-24 months. In a multivariate regression model, higher basel

SUBMITTER: Erez G 

PROVIDER: S-EPMC4941231 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature