LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway.

ABSTRACT: Accumulating evidence suggests that long noncoding RNAs (lncRNAs) play important roles in transcriptional regulation, whereas the extent to which the lncRNAs also function at the posttranscriptional level is less known. In the present study, we report a lncRNA named MT1JP which acts as a tumor suppressor through a posttranscriptional mechanism. We found that MT1JP is differentially expressed in tumor tissues by analyzing data from a customized microarray applied to 76 pairs of matched normal and cancer tissue samples. By associating with the RNA-binding protein TIAR, MT1JP enhanced the translation of the master transcription factor p53, thereby regulating a series of pathways involving p53, such as the cell cycle, apoptosis and proliferation. When MT1JP was down-regulated, the protein leve

SUBMITTER: Liu L 

PROVIDER: S-EPMC4941277 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature