Ontology highlight
ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC4941312 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jiang Xiao X Wang Juan J Chen Xijuan X Hong Yun Y Wu Tong T Chen Xiaobing X Xia Juan J Cheng Bin B
Oncotarget 20160301 13
Chemokine (C-C motif) ligand 18 (CCL18) has been implicated in the pathogenesis and progression of various cancers; however, in oral squamous cell carcinoma (OSCC), the role of CCL18 is unknown. In this study, we found that CCL18 was overexpressed in primary OSCC tissues and was associated with an advanced clinical stage. CCL18 was found in both the cytoplasm and cell membrane of OSCC cells and was predominantly produced by cancer epithelial cells, as opposed to tumor-infiltrating macrophages. I ...[more]