High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator.

ABSTRACT: Prostate cancer remains a deadly disease especially when patients become resistant to drugs that target the Androgen Receptor (AR) ligand binding domain. At this stage, patients develop recurring castrate-resistant prostate cancers (CRPCs). Interestingly, CRPC tumors maintain dependency on AR for growth; moreover, in CRPCs, constitutively active AR splice variants (e.g., AR-V7) begin to be expressed at higher levels. These splice variants lack the ligand binding domain and are rendered insensitive to current endocrine therapies. Thus, it is of paramount importance to understand what regulates the expression of AR and its splice variants to identify new therapeutic strategies in CRPCs. Here, we used high throughput microscopy and quantitative image analysis to evaluate effects of selected e

SUBMITTER: Stossi F 

PROVIDER: S-EPMC4941363 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature