Lipid profile of platelets and platelet-derived microparticles in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer patients have a high risk of developing venous thrombosis. The membrane lipid bilayer of platelets and platelet-derived microparticles (PMP) provides a platform for assembly of coagulation proteins and generation of blood clots.

Methods

We compared the lipid composition of platelets and PMPs in patients with ovarian cancer to those in healthy subjects. We used shotgun lipidomics to quantify 12 classes and 177 species of lipids.

Results

We found a significant change in 2 classes of lipids in platelets and PMPs isolated from ovarian cancer patients: higher phosphatidylinositol and lower lyso-phosphatidylcholine. The level of 28 species of lipids was also significantly altered in the direction of an increase in the pro-coagulant and a reduction

SUBMITTER: Hu Q 

PROVIDER: S-EPMC4941562 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature