The BestFIT trial: A SMART approach to developing individualized weight loss treatments.

ABSTRACT: Behavioral weight loss programs help people achieve clinically meaningful weight losses (8-10% of starting body weight). Despite data showing that only half of participants achieve this goal, a "one size fits all" approach is normative. This weight loss intervention science gap calls for adaptive interventions that provide the "right treatment at the right time for the right person." Sequential Multiple Assignment Randomized Trials (SMART), use experimental design principles to answer questions for building adaptive interventions including whether, how, or when to alter treatment intensity, type, or delivery. This paper describes the rationale and design of the BestFIT study, a SMART designed to evaluate the optimal timing for intervening with sub-optimal responders to weight loss treatmen

SUBMITTER: Sherwood NE 

PROVIDER: S-EPMC4941634 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature