An essential role of SVZ progenitors in cortical folding in gyrencephalic mammals.

ABSTRACT: Because folding of the cerebral cortex in the mammalian brain is believed to be crucial for higher brain functions, the mechanisms underlying its formation during development and evolution are of great interest. Although it has been proposed that increased neural progenitors in the subventricular zone (SVZ) are responsible for making cortical folds, their roles in cortical folding are still largely unclear, mainly because genetic methods for gyrencephalic mammals had been poorly available. Here, by taking an advantage of our newly developed in utero electroporation technique for the gyrencephalic brain of ferrets, we investigated the role of SVZ progenitors in cortical folding. We found regional differences in the abundance of SVZ progenitors in the developing ferret brain even before cort

SUBMITTER: Toda T 

PROVIDER: S-EPMC4941724 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature