Transcriptional characteristics of different sized follicles in relation to embryo transferability: potential role of hepatocyte growth factor signalling.

ABSTRACT:

Study hypothesis

We hypothesized that a better discrimination between follicles containing oocytes with high developmental competence and those containing oocytes with low competence, based on a combination of a follicle's size and transcriptomic signature, will provide a reliable method to predict embryonic outcome of IVF.

Study finding

This study provides new insights on the impact of follicular size on oocyte quality as measured by embryonic development and demonstrates that medium follicles yield a better percentage of transferable embryos.

What is known already

Although it is generally accepted that large ovarian follicles contain better eggs, other studies report that a better follicular size subdivision and a better characterization are needed.

Study design,

SUBMITTER: Nivet AL 

PROVIDER: S-EPMC4941807 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature