Acute Metabolic Influences on the Natriuretic Peptide System in Humans.

ABSTRACT:

Background

The cardiac natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), have central roles in sodium and blood pressure regulation. Extracardiac factors (e.g., obesity and diabetes) influence NP production, potentially altering cardiovascular responses to volume and pressure stress.

Objectives

This study examined the effects of acute carbohydrate intake on the NP system in humans, and investigated underlying mechanisms.

Methods

Normotensive subjects (N = 33) were given a high-carbohydrate shake. Venous blood was sampled to measure N-terminal (NT)-proANP and NT-proBNP levels. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and HepG2 cells were treated with glucose, and expression levels of NPs and micro ribo

SUBMITTER: Arora P 

PROVIDER: S-EPMC4941828 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature