Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.

ABSTRACT: The fetal origins of disease hypothesis suggests that variations in the course of prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support the existence of differences in the developing lung trajectory in males and females, and sex-specific differences in the prevalence of chronic lung diseases, such as asthma and bronchopulmonary dysplasia. The objectives of this study were to investigate the early developing fetal lung for transcriptomic correlates of postconception age (maturity) and sex, and their associations with chronic lung diseases. We analyzed whole-lung transcriptome profiles of 61 females and 78 males at 54-127 days postconception (dpc) from nonsmoking mothers using unsupervised principal component analysis and su

SUBMITTER: Kho AT 

PROVIDER: S-EPMC4942221 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature