Cell line modeling to study biomarker panel in prostate cancer.

ABSTRACT:

Background

African-American men with prostate cancer (PCa) present with higher-grade and -stage tumors compared to Caucasians. While the disparity may result from multiple factors, a biological basis is often strongly suspected. Currently, few well-characterized experimental model systems are available to study the biological basis of racial disparity in PCa. We report a validated in vitro cell line model system that could be used for the purpose.

Methods

We assembled a PCa cell line model that included currently available African-American PCa cell lines and LNCaP (androgen-dependent) and C4-2 (castration-resistant) Caucasian PCa cells. The utility of the cell lines in studying the biological basis of variance in a malignant phenotype was explored using a multiplex biomarker

SUBMITTER: NickKholgh B 

PROVIDER: S-EPMC4942245 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature