The hippocampus participates in a pharmacological rat model of absence seizures.

ABSTRACT:

Objective

Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6 Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs.

Methods

Local field potentials were recorded by chronically implanted depth electrodes in the neocortex (frontal, parietal, visual), ventrolateral thalamus and dorsal hippocampal CA1 area. In separate experiments, multiple unit recordings were made at the hippocampal CA1 pyramidal cell layer, or the mid-septotemporal hippocampus was inactivated by local infusion of GABAA receptor agonist muscimol.

Results

As PDs developed following GBL injection, coherence of local field p

SUBMITTER: Arcaro J 

PROVIDER: S-EPMC4942264 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature