Is solvent/detergent plasma better than standard fresh-frozen plasma? A systematic review and an expert consensus document.

ABSTRACT:

Background

Only a few studies have compared solvent/detergent plasma (SD-plasma) to standard fresh-frozen plasma (FFP) in terms of efficacy and safety.

Materials and methods

A systematic review was performed in order to develop a consensus document on the use of SD-plasma. Moreover, a pharmacoeconomic study was performed in order to assess whether the use of SD-plasma can be cost-effective with respect to the use of FFP. A multidisciplinary panel used the systematic review and the GRADE methodology to develop evidence-based recommendations on this topic.

Results

Based on moderate to very low quality evidence, the panel developed the following consensus statements: (i) the panel suggested that SD-plasma is safer than FFP; (ii) the panel could not express for or against

SUBMITTER: Marietta M 

PROVIDER: S-EPMC4942317 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature