Did death certificates and a death review process agree on lung cancer cause of death in the National Lung Screening Trial?

ABSTRACT:

Background/aims

Randomized controlled trials frequently use death review committees to assign a cause of death rather than relying on cause of death information from death certificates. The National Lung Screening Trial, a randomized controlled trial of lung cancer screening with low-dose computed tomography versus chest X-ray for heavy and/or long-term smokers ages 55-74 years at enrollment, used a committee blinded to arm assignment for a subset of deaths to determine whether cause of death was due to lung cancer.

Methods

Deaths were selected for review using a pre-determined computerized algorithm. The algorithm, which considered cancers diagnosed during the trial, causes and significant conditions listed on the death certificate, and the underlying cause of death derived

SUBMITTER: Marcus PM 

PROVIDER: S-EPMC4942331 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature