Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

ABSTRACT: Altered tissue structure is a feature of many disease states and is usually measured by microscopic methods, limiting analysis to small areas. Means to rapidly and quantitatively measure the structure and organisation of large tissue areas would represent a major advance not just for research but also in the clinic. Here, changes in tissue organisation that result from heterozygosity in Apc, a precancerous situation, are comprehensively measured using microultrasound and three-dimensional high-resolution microscopy. Despite its normal appearance in conventionally examined cross-sections, both approaches revealed a significant increase in the variability of tissue organisation in Apc heterozygous tissue. These changes preceded the formation of aberrant crypt foci or adenoma. Measuring these

SUBMITTER: Fatehullah A 

PROVIDER: S-EPMC4942766 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature