Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.

ABSTRACT:

Background

Changes to the epigenome with aging, and DNA modifications in particular, have been proposed as a central regulator of the aging process, a predictor of mortality, and a contributor to the pathogenesis of age-related diseases. In the central nervous system, control of learning and memory, neurogenesis, and plasticity require changes in cytosine methylation and hydroxymethylation. Although genome-wide decreases in methylation with aging are often reported as scientific dogma, primary research reports describe decreases, increases, or lack of change in methylation and hydroxymethylation and their principle regulators, DNA methyltransferases and ten-eleven translocation dioxygenases in the hippocampus. Furthermore, existing data are limited to only male animals.

Results<

SUBMITTER: Hadad N 

PROVIDER: S-EPMC4942942 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature