Antigenic drift of H1N1 influenza A virus in pigs with and without passive immunity.

ABSTRACT:

Background

The genetic and antigenic characteristics of influenza A viruses (IAV) within and between species change over time due to antigenic shift and drift. Although pigs are known to play a key role in the epidemiology of IAV between species, little is known about the molecular evolution of IAV hemagglutinin (HA) in pigs.

Objectives

The aim of this study was to evaluate the HA drift of an H1N1 IAV after infecting weaned pigs with or without maternally derived passive immunity.

Methods

Three- to four-week-old piglets born either to vaccinated or unvaccinated sows were contact-infected upon exposure with an IAV-infected pig. Nasal swabs were collected daily from each pig and tested for IAV by RRT-PCR. Full-length HA sequences were obtained directly from positive nas

SUBMITTER: Diaz A 

PROVIDER: S-EPMC4942991 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature