Paroxetine exposure skews litter sex ratios in mice suggesting a Trivers-Willard process.

ABSTRACT: While conducting a toxicity assessment of the antidepressant paroxetine (Paxil®), in wild-derived mice (Mus musculus), we observed that exposed dams (P₀) produced female biased litters (32:68 M:F). Though numerous experimental manipulations have induced sex ratio bias in mice, none have assessed the fitness of the offspring from these litters relative to controls. Here, we retrospectively analyze experimentally derived fitness data gathered for the purpose of toxicological assessment in light of 2 leading hypothesis (Trivers-Willard hypothesis [TWH] and cost of reproduction hypothesis [CRH]), seeking to test if this facultative sex ratio adjustment fits into an adaptive framework. Control F₁ males were heavier than F₁ females, but no differences in m

SUBMITTER: Gaukler SM 

PROVIDER: S-EPMC4943110 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature