Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.

ABSTRACT: All eukaryotic genomes encode multiple members of the heat shock protein 70 (HSP70) family, which evolved distinctive structural and functional features in response to specific environmental constraints. Phylogenetic analysis of this protein family thus can inform on genetic and molecular mechanisms that drive species-specific environmental adaptation. Here we use the eukaryotic pathogen Leishmania spp. as a model system to investigate the evolution of the HSP70 protein family in an early-branching eukaryote that is prone to gene amplification and adapts to cytotoxic host environments by stress-induced and chaperone-dependent stage differentiation. Combining phylogenetic and comparative analyses of trypanosomatid genomes, draft genome of Paratrypanosoma and recently published genome sequen

SUBMITTER: Drini S 

PROVIDER: S-EPMC4943205 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature