Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.

ABSTRACT:

Context

The arteriovenous fistula is the preferred type of vascular access for hemodialysis because of lower thrombosis and infection rates and lower health care expenditures compared with synthetic grafts or central venous catheters. Early failure of fistulas due to thrombosis or inadequate maturation is a barrier to increasing the prevalence of fistulas among patients treated with hemodialysis. Small, inconclusive trials have suggested that antiplatelet agents may reduce thrombosis of new fistulas.

Objective

To determine whether clopidogrel reduces early failure of hemodialysis fistulas.

Design, setting, and participants

Randomized, double-blind, placebo-controlled trial conducted at 9 US centers composed of academic and community nephrology practices in 2003-2007.

SUBMITTER: Dember LM 

PROVIDER: S-EPMC4943222 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature