Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study.

ABSTRACT:

Background

Carotid atherosclerosis is associated with subclinical ischemic cerebrovascular disease, but its role in hemorrhage-prone small vessel disease-represented by cerebral microbleed (CMB)-is unclear, although vascular risk factors underlie both conditions. We hypothesized that persons with carotid atherosclerosis would have higher risk of CMB, particularly in deep regions.

Methods and results

We studied 1243 participants in the Framingham Offspring Study (aged 56.9±8.8 years; 53% women) with carotid ultrasound available on 2 occasions (1995-1998 and 2005-2008) prior to brain magnetic resonance imaging. Using multivariable logistic regression, we related baseline carotid stenosis, baseline intima-media thickness, and site-specific carotid intima-media thickness progres

SUBMITTER: Romero JR 

PROVIDER: S-EPMC4943235 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature