Subtype-Specific Interactions and Prognosis in Cardiac Amyloidosis.

ABSTRACT:

Background

Light chain (AL) and transthyretin (ATTR) amyloidosis have a similar effect on myocardial function but very different disease trajectories and survival. However, limited data are available evaluating subtype-specific predictors of outcomes in a large contemporary cohort.

Methods and results

We retrospectively investigated 360 patients at the time of initial diagnosis of cardiac amyloidosis (191 AL and 169 ATTR) from 2002 to 2014. Clinical, laboratory, electrical, and morphologic covariates were evaluated based upon amyloid subtype. ATTR etiology was associated with older age, more chronic medical conditions, and the use of standard heart failure medical therapy. Left ventricular mass index and electrocardiographic voltage were higher in ATTR, while there was no di

SUBMITTER: Sperry BW 

PROVIDER: S-EPMC4943263 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature