Schwann Cells Migration on Patterned Polydimethylsiloxane Microgrooved Surface.

ABSTRACT: Schwann cells (SCs) aid in nerve repair in the peripheral nervous system, and their ability to migrate into the injury site is critical for nerve regeneration after injury. The majority of studies on SC behavior have focused on SC alignment through contact guidance, rather than migration. The few studies on SC migration primarily investigated the migration of individual cells over several hours with time-lapse microscopy. However, during neural tissue repair, SCs do not migrate as single cells but as a population of cells over physiologically relevant time and length scales. Thus from a practical perspective, there is a need to understand the migration of large populations of SC and the collective guidance cues from the surrounding environment in designing optimal transplantable scaffolds.

SUBMITTER: Liu C 

PROVIDER: S-EPMC4943468 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature