Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels.

ABSTRACT:

Background

Prostatic Acid Phosphatase (PAP) is an enzyme that is produced primarily in the prostate and functions as a cell growth regulator and potential tumor suppressor. Understanding the genetic regulation of this enzyme is important because PAP plays an important role in prostate cancer and is expressed in other tissues such as the brain.

Methods

We tested association between 5.8 M SNPs and PAP levels in cerebrospinal fluid across 543 individuals in two datasets using linear regression. We then performed meta-analyses using METAL =with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets, identifying 289 candidate SNPs that affect PAP cerebrospinal fluid levels. We analyzed each of these SNP

SUBMITTER: Staley LA 

PROVIDER: S-EPMC4943489 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature