Presenilin E318G variant and Alzheimer's disease risk: the Cache County study.

ABSTRACT:

Background

Alzheimer's disease is the leading cause of dementia in the elderly and the third most common cause of death in the United States. A vast number of genes regulate Alzheimer's disease, including Presenilin 1 (PSEN1). Multiple studies have attempted to locate novel variants in the PSEN1 gene that affect Alzheimer's disease status. A recent study suggested that one of these variants, PSEN1 E318G (rs17125721), significantly affects Alzheimer's disease status in a large case-control dataset, particularly in connection with the APOEε4 allele.

Methods

Our study looks at the same variant in the Cache County Study on Memory and Aging, a large population-based dataset. We tested for association between E318G genotype and Alzheimer's disease status by running a series of Fis

SUBMITTER: Hippen AA 

PROVIDER: S-EPMC4943516 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature