Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.

ABSTRACT: Neurogranin is a calmodulin binding protein that has been implicated in learning and memory, long-term potentiation and synaptic plasticity. Neurons expressing neurogranin in the cortex degenerate in late stages of Parkinson's disease with widespread α-synuclein pathology. While analyzing neurogranin gene expression levels through rtPCR in brains of mouse models overexpressing human α-synuclein, we found levels were elevated 2.5 times when compared to nontransgenic animals. Immunohistochemistry in the cortex revealed colocalization between α-synuclein and neurogranin in mouse transgenics when compared to control mice. Coimmunoprecipitation studies in the superior temporal cortex in humans confirmed interaction between α-synuclein and neurogranin, and decreased interaction between α-synucle

SUBMITTER: Koob AO 

PROVIDER: S-EPMC4943923 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature