MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b.

ABSTRACT: Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequent failure of NCC patterning and differentiation into bone and cartilage. While loss of gene expression is often associated with developmental defects, aberrant upregulation of expression can also be detrimental. microRNAs (miRNAs) are a class of non-coding RNAs that normally repress gene expression by binding to recognition sequences located in the 3' UTR of target mRNAs. miRNAs play important roles in many developmental systems, including midfacial development. Here, we take

SUBMITTER: Ding HL 

PROVIDER: S-EPMC4943961 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature