Oncomirs miRNA-221/222 and Tumor Suppressors miRNA-199a/195 Are Crucial miRNAs in Liver Cancer: A Systematic Analysis.

ABSTRACT:

Background

The high mortality rate of hepatocellular carcinoma (HCC) is partly due to a lack of good diagnostic markers and treatment strategies. Recently, several microRNA (miRNA) profiling studies were conducted with HCC; however, their inconsistency means that their diagnostic or therapeutic value is debatable.

Aims

This study aims to systematically evaluate the consistency of miRNAs from multiple independent studies.

Methods

A systematic analysis of miRNAs from eligible publications was conducted, followed by real-time PCRs. The targets of highly consistent miRNAs were collected using online programs, followed by enrichment analyses for gene ontology terms and Kyoto encyclopedia of genes and genomes pathways.

Results

In total, 241 differentially expressed m

SUBMITTER: Li Y 

PROVIDER: S-EPMC4943968 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature