Regulatory Requirements for Staphylococcus aureus Nitric Oxide Resistance.

ABSTRACT:

Unlabelled

The ability of Staphylococcus aureus to resist host innate immunity augments the severity and pervasiveness of its pathogenesis. Nitric oxide (NO˙) is an innate immune radical that is critical for the efficient clearance of a wide range of microbial pathogens. Exposure of microbes to NO˙ typically results in growth inhibition and induction of stress regulons. S. aureus, however, induces a metabolic state in response to NO˙ that allows for continued replication and precludes stress regulon induction. The regulatory factors mediating this distinctive response remain largely undefined. Here, we employ a targeted transposon screen and transcriptomics to identify and characterize five regulons essential for NO˙ resistance in S. aureus: three virulence regulons not formerly as

SUBMITTER: Grosser MR 

PROVIDER: S-EPMC4944221 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature