CodY-Dependent Regulation of Sporulation in Clostridium difficile.

ABSTRACT:

Unlabelled

Clostridium difficile must form a spore to survive outside the gastrointestinal tract. The factors that trigger sporulation in C. difficile remain poorly understood. Previous studies have suggested that a link exists between nutritional status and sporulation initiation in C. difficile In this study, we investigated the impact of the global nutritional regulator CodY on sporulation in C. difficile strains from the historical 012 ribotype and the current epidemic 027 ribotype. Sporulation frequencies were increased in both backgrounds, demonstrating that CodY represses sporulation in C. difficile The 027 codY mutant exhibited a greater increase in spore formation than the 012 codY mutant. To determine the role of CodY in the observed sporulation phenotypes, we examined se

SUBMITTER: Nawrocki KL 

PROVIDER: S-EPMC4944225 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature