Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis.

ABSTRACT:

Background

Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinical pain measures, it is unknown whether individual variability in quantitative sensory testing (QST) responses at baseline can prospectively predict analgesic treatment responses.

Method

Patients with knee OA (n = 35) were compared on QST responses to a demographically-matched pain-free control group (n = 39), after which patients completed a month-long treatment study of diclofenac sodium topical gel (1 %), applied up to 4 times daily.

Results

OA patients demonstrated reduced pain thresholds at multiple anatomic sites, as well as reduced conditioned pa

SUBMITTER: Edwards RR 

PROVIDER: S-EPMC4944243 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature